# Single‐cell and spatial transcriptomics uncover neoadjuvant chemotherapy‐resistant malignant cells with inhibitory signalling on B cells in gastric cancer **Authors:** Pei‐Yi Han, Xiang‐Xi Ye, Xiao Yang, Lin Li, Xuan Zhao, Yan‐Fei Shao, Jing Sun, Lu Zang, Ze‐Guang Han, Min‐Hua Zheng PMC · DOI: 10.1002/ctm2.70600 · Clinical and Translational Medicine · 2026-02-02 ## Full-text entities - **Genes:** CD74 (CD74 molecule) [NCBI Gene 972] {aka CLIP, DHLAG, HLADG, II, Ia-GAMMA, p33}, TFG (trafficking from ER to golgi regulator) [NCBI Gene 10342] {aka HMSNP, SPG57, TF6, TRKT3}, CD83 (CD83 molecule) [NCBI Gene 9308] {aka BL11, HB15}, HOXA11 (homeobox A11) [NCBI Gene 3207] {aka HOX1, HOX1I, RUSAT1}, ABCB1 (ATP binding cassette subfamily B member 1) [NCBI Gene 5243] {aka ABC20, CD243, CLCS, ENPAT, GP170, MDR1}, Spp1 (secreted phosphoprotein 1) [NCBI Gene 20750] {aka 2AR, Apl-1, BNSP, BSPI, Bsp, ETA-1}, MCL1 (MCL1 apoptosis regulator, BCL2 family member) [NCBI Gene 4170] {aka BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1}, PRDM9 (PR/SET domain 9) [NCBI Gene 56979] {aka KMT8B, MEISETZ, MSBP3, PFM6, ZNF899}, WWTR1 (WW domain containing transcription regulator 1) [NCBI Gene 25937] {aka TAZ}, GATA2 (GATA binding protein 2) [NCBI Gene 2624] {aka DCML, IMD21, MONOMAC, NFE1B}, XIAP (X-linked inhibitor of apoptosis) [NCBI Gene 331] {aka API3, BIRC4, IAP-3, ILP1, MIHA, XLP2}, CXCR4 (C-X-C motif chemokine receptor 4) [NCBI Gene 7852] {aka CD184, D2S201E, FB22, HM89, HSY3RR, LCR1}, RAMP1 (receptor activity modifying protein 1) [NCBI Gene 10267], ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1) [NCBI Gene 25820] {aka ARI, HARI, HHARI, UBCH7BP}, CD44 (CD44 molecule (IN blood group)) [NCBI Gene 960] {aka CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL}, TAL2 (TAL bHLH transcription factor 2) [NCBI Gene 6887] {aka TAL-2}, XBP1 (X-box binding protein 1) [NCBI Gene 7494] {aka TREB-5, TREB5, XBP-1, XBP2}, CCNB1 (cyclin B1) [NCBI Gene 891] {aka CCNB}, GRIN1 (glutamate ionotropic receptor NMDA type subunit 1) [NCBI Gene 2902] {aka DEE101, GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1}, EPB41L3 (erythrocyte membrane protein band 4.1 like 3) [NCBI Gene 23136] {aka 4.1B, DAL-1, DAL1}, Cd44 (CD44 antigen) [NCBI Gene 12505] {aka HERMES, Ly-24, Pgp-1}, HSPA1B (heat shock protein family A (Hsp70) member 1B) [NCBI Gene 3304] {aka HSP70-1, HSP70-1B, HSP70-2, HSP70.1, HSP70.2, HSP72}, CDKN1A (cyclin dependent kinase inhibitor 1A) [NCBI Gene 1026] {aka CAP20, CDKN1, CIP1, MDA-6, P21, SDI1}, PLA2G2A (phospholipase A2 group IIA) [NCBI Gene 5320] {aka MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1}, JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 3726] {aka AP-1}, FKBP11 (FKBP prolyl isomerase 11) [NCBI Gene 51303] {aka FKBP19}, ATR (ATR checkpoint kinase) [NCBI Gene 545] {aka FCTCS, FRP1, MEC1, SCKL, SCKL1}, SPP1 (secreted phosphoprotein 1) [NCBI Gene 6696] {aka BNSP, BSPI, ETA-1, OPN}, NSD1 (nuclear receptor binding SET domain protein 1) [NCBI Gene 64324] {aka ARA267, KMT3B, SOTOS, SOTOS1, STO}, TXN (thioredoxin) [NCBI Gene 7295] {aka TRDX, TRX, TRX1, TXN1, Trx80}, CFLAR (CASP8 and FADD like apoptosis regulator) [NCBI Gene 8837] {aka CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1}, Cd86 (CD86 antigen) [NCBI Gene 12524] {aka B7, B7-2, B7.2, B70, CLS1, Cd28l2}, MIF (macrophage migration inhibitory factor) [NCBI Gene 4282] {aka GIF, GLIF, MMIF}, TNFRSF17 (TNF receptor superfamily member 17) [NCBI Gene 608] {aka BCM, BCMA, CD269, TNFRSF13A} - **Diseases:** Tumour (MESH:D009369), GC (MESH:D013274) - **Chemicals:** aflatoxin (MESH:D000348), ATP (MESH:D000255), COMMOT (-), XELOX (MESH:C519688) - **Species:** Homo sapiens (human, species) [taxon 9606] - **Cell lines:** EPI1-7 — Neovison vison (American mink), Transformed cell line (CVCL_6397) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12865221/full.md ## Figures 4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12865221/full.md ## References 10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12865221/full.md --- Source: https://tomesphere.com/paper/PMC12865221