# Research Progress of Interstitial Lung Disease Based on Single‐Cell Sequencing Technology

## TL;DR

This paper reviews how single-cell sequencing is helping to better understand interstitial lung diseases like IPF and CTD-ILD.

## Contribution

The paper provides a review of recent advances in using single-cell sequencing for studying major interstitial lung diseases.

## Key findings

- Single-cell sequencing has revealed new insights into the mechanisms of idiopathic pulmonary fibrosis.
- The technology has improved understanding of connective tissue disease–associated ILD.
- Future research priorities include expanding single-cell sequencing applications in ILD studies.

## Abstract

Interstitial lung disease (ILD) refers to a collection of respiratory conditions characterized by inflammation of the lung parenchyma, alveolar irritation, and fibrosis of the interstitial tissue. Traditional research methods are often unable to completely reveal the complex mechanism of ILD occurrence and development. However, advancements in single‐cell sequencing technology in recent years have opened up a novel avenue for investigating ILD. This review summarizes recent single‐cell‐sequencing advances in the major interstitial lung diseases—idiopathic pulmonary fibrosis (IPF), pneumoconiosis, and connective tissue disease–associated ILD (CTD‐ILD)—and outlines future research priorities.