# Inflammatory cytokines and quality of life response to weight reduction in obese patients with bronchial asthma

## TL;DR

This study shows that weight loss improves quality of life and reduces inflammation in obese asthma patients.

## Contribution

The study demonstrates that lifestyle interventions can positively affect inflammatory markers and quality of life in obese asthmatics.

## Key findings

- Weight loss improved HRQL scores, IL-10, and ACT in obese asthmatic patients.
- BMI, TNF-α, and IL-6 levels decreased significantly with weight reduction.
- No significant differences were observed between groups at the end of the study.

## Abstract

Globally, about 20% of the population are affected with asthma. However, public health is adversely affected with asthma and obesity.

The target of the present study was to measure influence of weight loss on quality of life and Inflammatory cytokines of obese asthmatic patients.

Eighty obese asthmatic patients; the mean of their age was 42.71 ± 6.35 year and body mass index (BMI) was 32.85 ± 3.16 Kg/m2. Participants equally assigned in group (A) received weight reducing program, where group (B) received no therapeutic intervention.

The Health-related quality of life (SF-36 HRQL) subscale scores, interleukin-10 (IL-10) and Asthma Control Test (ACT) improved significantly, where, the mean values of BMI, TNF-α and IL-6 were significantly reduced in group (A). While group (B) had no significant changes in their parameters. In addition, the differences between both groups were not significant at the end of the study.

Inflammatory cytokines and quality of life parameters improved with lifestyle modification among obese asthmatic patients.