# Glycosylation Profiles in Cardiovascular Diseases: A Bibliometric Analysis

## TL;DR

This paper uses bibliometric analysis to study how glycosylation research in cardiovascular diseases has evolved, highlighting key trends and hotspots like O-GlcNAcylation.

## Contribution

The study provides a comprehensive bibliometric analysis of glycosylation in CVDs, identifying emerging research hotspots and trends.

## Key findings

- The United States and China are the leading contributors to glycosylation and CVD research.
- O-GlcNAcylation is identified as a pivotal research hotspot in the field.
- Key research areas include biomarkers, angiogenesis, and cardiac glycosides.

## Abstract

Background: Cardiovascular diseases (CVDs) continue to be the leading cause of morbidity and mortality globally, indicating a major global health burden. Glycosylation, one of the key posttranslational modifications of proteins, plays an important role in the onset and progression of CVDs. This study employed bibliometric analysis to examine the research on glycosylation and CVDs, aiming to identify the evolution and hotspots in this field. Methods: A total of 1,441 publications published from 2010 January 1 to 2024 December 31 were extracted from the Web of Science Core Collection. The analysis included a visual and descriptive examination of publication trends, countries/regions, institutions, keywords, and references. Results: The United States is the most productive country/region in this field, followed closely by China. The University of Alabama at Birmingham has made the most important contribution to this area. Key research hotspots include “O-GlcNAcylation”, “biomarkers”, “angiogenesis”, “α-dystroglycan”, “potassium channel”, “heart failure”, “gene expression”, “glycosylation”, and “cardiac glycosides”. Conclusion: Research on glycosylation in CVDs has shown a steady increase in recent years. Among these studies, O-GlcNAcylation plays a pivotal role in this field. This comprehensive bibliometric analysis of glycosylation and CVDs provides researchers with valuable, objective insights to support future investigations.