# A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

## TL;DR

This systematic review summarizes the natural sources, biosynthesis, and diverse therapeutic effects of the bioactive compound Atractylone.

## Contribution

The first comprehensive review on Atractylone following PRISMA guidelines, consolidating its pharmacological properties and mechanisms.

## Key findings

- Atractylone shows anticancer, antimicrobial, and neuroprotective activities.
- The compound is derived from natural sources and has multiple biological targets.
- The review highlights gaps in research and provides a foundation for future studies.

## Abstract

Traditional Chinese medicine (TCM) has garnered considerable attention due to its multifaceted therapeutic potential, characterized by a broad spectrum of pharmacological activities, multiple biological targets, and a generally favorable safety profile. Atractylone, a bioactive sesquiterpenoid, has been noted to exhibit numerous pharmacological effects, including cytotoxic, antimicrobial, anti‐inflammatory, antiviral, anticancer, antioxidant, neuroprotective, and gastroprotective activities. The isolation and structural characterization of this compound are essential for optimizing its pharmacological applications and unlocking its full therapeutic potential. Despite its promising bioactivity, to our knowledge, no comprehensive review has yet been dedicated to summarizing the current state of research on Atractylone. To tackle this gap, we conducted a systematic review following the PRISMA guidelines to define a clear research question and methodology. A comprehensive literature search was performed using PubMed, Scopus, Web of Science, and Google Scholar to collect all available information on Atractylone. This review aims to furnish a detailed analysis of its natural sources, biosynthetic pathways, and biological activities. By summarizing current knowledge, this article establishes a foundation for future research and encourages further exploration of Atractylone's therapeutic applications.

Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential. The review establishes a foundation for future research on Atractylone's applications.