# Beyond the clot: how the biomolecular landscape of platelet-rich fibrin directs fibroblast functions

## TL;DR

This paper reviews how Platelet-Rich Fibrin (PRF) helps heal wounds by influencing fibroblast activity in regenerative medicine.

## Contribution

The paper provides a comprehensive review of PRF's role in modulating fibroblast functions for tissue regeneration.

## Key findings

- PRF acts as a biologically active scaffold that accelerates soft tissue repair.
- PRF modulates fibroblast functions related to extracellular matrix synthesis and inflammation.
- PRF is effective in various clinical applications including dentistry and plastic surgery.

## Abstract

Platelet-Rich Fibrin (PRF) is a second-generation autologous blood concentrate widely applied in regenerative medicine and dentistry for its wound-healing potential. Its clinical applications span dermatology, plastic surgery, periodontology, implantology, and oral maxillofacial surgery, with growing evidence supporting its effectiveness in tissue regeneration. Fibroblasts, as central regulators of extracellular matrix synthesis and remodeling, angiogenesis, and inflammation, are important targets of PRF's regenerative effects. This review summarizes the recent evidence of role of PRF in regulation of fibroblast functions important for wound healing and inflammation. It highlights PRF as a biologically active scaffold that accelerates soft tissue repair, primarily through modulation of fibroblasts, positioning it as a promising adjunct in regenerative therapies.