# Bladder Paraganglioma With Rapid Metastasis: A Case Report and Review of the Literature

**Authors:** James Turney, Gabrielle R Yankelevich, Matvey Tsivian

PMC · DOI: 10.7759/cureus.100705 · Cureus · 2026-01-03

## TL;DR

A rare case of bladder paraganglioma with rapid metastasis is reported, highlighting the importance of considering this tumor in patients with hematuria.

## Contribution

This case report adds to the limited literature on metastatic bladder paraganglioma and emphasizes social determinants affecting treatment.

## Key findings

- Bladder paraganglioma can metastasize rapidly within three months.
- Social determinants of health impacted the patient's ability to maintain medical appointments.
- Paraganglioma should be considered in the differential diagnosis of hematuria.

## Abstract

Bladder paragangliomas (bPGLs) are extremely rare tumors, and we present a unique case of metastatic bPGL that developed within three months. Frequently, these tumors are related to a hereditary syndrome due to germline mutations in succinate dehydrogenase B (SDHB). A unique challenge in this case was related to social determinants of health, which, in this patient, were associated with difficulty maintaining appointments. In treating a patient with hematuria, it is important to consider paraganglioma (PGL) as a differential diagnosis to optimize treatment.

## Linked entities

- **Genes:** SDHB (succinate dehydrogenase complex iron sulfur subunit B) [NCBI Gene 6390]

## Full-text entities

- **Genes:** SDHB (succinate dehydrogenase complex iron sulfur subunit B) [NCBI Gene 6390] {aka CWS2, IP, MC2DN4, PGL4, PPGL4, SDH}
- **Diseases:** tumors (MESH:D009369), Bladder Paraganglioma (MESH:D010235), hematuria (MESH:D006417), hereditary syndrome (MESH:D009386)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12863712/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12863712/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12863712/full.md

---
Source: https://tomesphere.com/paper/PMC12863712