# Vanishing Bile Duct Syndrome as a Rare Complication of Classic Hodgkin's Lymphoma: A Case Report and Literature Review

## TL;DR

A rare case of Vanishing Bile Duct Syndrome occurring alongside Hodgkin's Lymphoma is reported, highlighting the need for early treatment and collaboration between specialists.

## Contribution

This case report adds to the limited literature on VBDS as a complication of classic Hodgkin's lymphoma.

## Key findings

- A patient with classic Hodgkin's lymphoma developed Vanishing Bile Duct Syndrome.
- Liver biopsy showed bile duct paucity without lymphoma involvement.
- Partial liver recovery was observed with cHL-directed treatment.

## Abstract

Vanishing bile duct syndrome (VBDS) is an acquired condition of progressive intrahepatic bile duct loss, resulting in severe cholestasis. Here, we present a case of VBDS in a patient with newly diagnosed classic Hodgkin's lymphoma (cHL). Our patient presented with cholestatic liver test elevations, including bilirubin and alkaline phosphatase. Liver biopsy confirmed the paucity of bile ducts and did not show involvement by lymphoma. Though the exact pathophysiology is unclear, it is postulated to be driven by cytokine release and T-lymphocyte cell dysregulation. Our patient has made a remarkable, albeit incomplete, liver recovery with cHL-directed treatment. Given the poor prognosis and higher mortality rate of VBDS, a multidisciplinary approach involving oncology, hepatology, and prompt initiation of dose-adjusted chemotherapy is imperative.