# A Case Report of a Patient Presenting With Extra-skeletal Myxoid Chondrosarcoma

## TL;DR

This case report describes a patient with a rare type of sarcoma called extra-skeletal myxoid chondrosarcoma, highlighting its characteristics, diagnosis, and treatment.

## Contribution

The paper presents a detailed clinical case of EMC, emphasizing its unique molecular marker and management challenges.

## Key findings

- EMC is characterized by the fusion gene EWSR1::NR4A3, a key diagnostic marker.
- Surgical removal is the primary treatment, while non-surgical options are used for recurrence or metastasis.
- EMC has a high risk of local recurrence and distant metastasis despite treatment.

## Abstract

Extra-skeletal myxoid chondrosarcoma (EMC) is a type of rare sarcoma of uncertain differentiation. This malignancy is marked by the growth of primitive chondroid cells forming multiple nodules within a rich myxoid matrix. It is distinguished by a specific translocation resulting in the fusion gene EWSR1::NR4A3, which is a distinctive molecular hallmark of EMC. EMC is categorised as an intermediate-grade tumour and is distinguished by a prolonged clinical course with a high likelihood of local recurrence and distant metastasis. Surgical treatment is the only option for a cure for EMC, while non-surgical treatments are typically considered for recurrent or distant disease. This case report discusses an interesting case of a patient with EMC and further elaborates on the history, examination, imaging, pathological findings, and management of EMC.