# Screwing the helical chirality through terminal peri-functionalization

## TL;DR

This paper discusses new methods for creating chiral helical molecules through peri-functionalization, an alternative to traditional approaches.

## Contribution

The paper introduces peri-functionalization as a novel pathway for generating chiral helical molecules.

## Key findings

- Peri-functionalization offers a new method for creating helical chirality in organic molecules.
- This approach provides an alternative to traditional ring extension methods for generating chiral helicity.

## Abstract

Helical chirality is an important, but underrated form of chirality than other types of chirality. Molecules with helical chirality impart a crucial role in several biological phenomena as well as in modern materials applications. Classically, the generation of chiral helicity in organic molecules relies on a ring extension by means of cycloaddition and related reactions. Recently, the peri-functionalization approach paved a new pathway for the generation of chiral helical molecules. In this article, we highlight the key advancements in these parallel approaches for the generation of helical chiral architectures.