# Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry

## TL;DR

This study explores gastrointestinal symptoms in systemic sclerosis patients and finds that these symptoms are linked to more severe disease and certain clinical features.

## Contribution

The study identifies new associations between gastrointestinal involvement and specific clinical and serological features in systemic sclerosis.

## Key findings

- GI symptoms are present in 56% of SSc patients and correlate with more severe disease.
- Female sex, dcSSc, ILD, and anti-centromere antibodies are linked to more extensive GI involvement.
- In VEDOSS patients, puffy fingers and anti-centromere antibodies predict early oesophageal symptoms.

## Abstract

To describe the prevalence of gastrointestinal (GI) symptoms in SSc and Very Early Diagnosis of SSc (VEDOSS), identify clinical and serological features associated with GI involvement and explore a cranio-caudal pattern of symptom distribution, using data from the Italian SPRING-SIR registry.

This cross-sectional analysis included patients fulfilling 2013 ACR/EULAR SSc or VEDOSS criteria. GI involvement was defined as symptoms in at least one GI tract segment and categorized as upper and lower. Associations between GI involvement and clinical variables were assessed using logistic and ordinal regression models, adjusting for demographics, disease characteristics and autoantibodies.

Among 1917 SSc patients, 56% had GI symptoms, associated with longer disease duration, dcSSc, interstitial lung disease (ILD), digital ulcers (DU), telangiectasias and tobacco exposure. Extensive GI involvement correlated with more severe disease. Ordinal regression identified female sex, dcSSc, ILD, DU, telangiectasias, tobacco exposure and anti-centromere antibodies as variables significantly associated with more extensive GI involvement. Disease duration did not show a significant association with GI symptom extent. Among 211 VEDOSS patients, 41.2% reported GI symptoms (mostly oesophageal), significantly associated with puffy fingers and dyspnoea. Among VEDOSS, puffy fingers and anti-centromere antibodies were independent predictors of presence of oesophageal symptoms.

GI involvement in SSc is linked to more severe disease and longer disease duration. Disease duration resulted linked to the presence of GI symptoms rather than extent of GI involvement. Puffy fingers and anti-centromere antibodies may associate with presence of early oesophageal symptoms in VEDOSS.