# Risk perception and influenza vaccine hesitancy among university students in Saudi Arabia

**Authors:** Faris S. Alnezary, Rama A. Alhejaili, Alaa A. Alayashi, Dina S. Alnizari, Nada S. Bin Mirdhah, Shaden K. Alrays, Saad Alobid, Fahad Alzahrani, Haifa A. Fadil, Waad Alrohily, Abrar K. Thabit, Mansour A. Mahmoud, Masaad S. Almutairi

PMC · DOI: 10.3389/fphar.2026.1747976 · Frontiers in Pharmacology · 2026-01-19

## TL;DR

This study explores why university students in Saudi Arabia are hesitant to get the flu vaccine, finding that perceived barriers, not lack of awareness, are the main issue.

## Contribution

The study identifies perceived barriers as the primary driver of vaccine hesitancy among Saudi university students, using the Health Belief Model framework.

## Key findings

- 62.4% of students reported significant barriers to vaccination despite high recognition of vaccine benefits.
- Female students were nearly twice as likely to report moderate barriers compared to males.
- Students with chronic conditions had higher vaccine acceptance (44.1%) compared to healthy peers (20.2%).

## Abstract

University campuses are high-risk environments for influenza transmission, yet vaccine coverage among students often remains suboptimal. This study aimed to identify the determinants of vaccine hesitancy among university students in Saudi Arabia using the Health Belief Model (HBM) framework.

A cross-sectional study was conducted between January and September 2024. Data were collected via a validated online Arabic questionnaire assessing HBM constructs—susceptibility, severity, benefits, and barriers—alongside sociodemographic variables. Ethical approval was obtained for human participation.

Of the 450 university students surveyed, 62.4% reported encountering significant barriers to vaccination. Despite a high recognition of vaccine benefits (66.7%), this awareness did not correlate with higher intention to vaccinate after adjusting for sociodemographic factors. Students perceiving fewer barriers exhibited substantially higher acceptance rates compared to those perceiving high barriers (60% vs. 27.8%). Furthermore, female students were nearly twice as likely to report moderate barriers (aOR = 1.994) compared to males, while healthcare students were significantly less likely to perceive such obstacles (aOR = 0.654). Students with chronic conditions also demonstrated higher vaccine acceptance (44.1%) compared to their healthy peers (20.2%).

Influenza vaccine uptake among Saudi university students is hindered primarily by perceived barriers rather than a lack of awareness regarding vaccine benefits. Public health strategies on campuses should shift focus from simply emphasizing advantages to actively mitigating logistical and misconception-based obstacles, particularly targeting non-healthcare disciplines and female students.

## Linked entities

- **Diseases:** influenza (MONDO:0005812)

## Full-text entities

- **Diseases:** influenza (MESH:D007251)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

44 references — full list in the complete paper: https://tomesphere.com/paper/PMC12862249/full.md

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Source: https://tomesphere.com/paper/PMC12862249