# Neuroblastoma: Anti‐Invasive Effects of Tetracaine In Vitro*

**Authors:** Ece Selçuk, David S. Silcock, Amanda Foust, Vicky Bousgouni, Mar Arias‐Garcia, Chris Bakal, Mustafa B. A. Djamgoz, Pinar Uysal‐Onganer

PMC · DOI: 10.1111/bcpt.70190 · Basic & Clinical Pharmacology & Toxicology · 2026-02-01

## Full-text entities

- **Genes:** SCN8A (sodium voltage-gated channel alpha subunit 8) [NCBI Gene 6334] {aka BFIS5, CERIII, CIAT, DEE13, EIEE13, MED}, RPL9 (ribosomal protein L9) [NCBI Gene 6133] {aka L9, NPC-A-16, uL6}, ELAVL1 (ELAV like RNA binding protein 1) [NCBI Gene 1994] {aka ELAV1, HUR, Hua, MelG}, GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1) [NCBI Gene 2907] {aka HNRGW, LFG1, NMDARA1, TMBIM3}, SCN5A (sodium voltage-gated channel alpha subunit 5) [NCBI Gene 6331] {aka CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD}
- **Diseases:** glioblastoma (MESH:D005909), oral squamous cell carcinoma (MESH:D000077195), NB (MESH:D009447), Cancer (MESH:D009369), metastasis (MESH:D009362), death (MESH:D003643), breast and colorectal cancers (MESH:D001943)
- **Chemicals:** lidocaine (MESH:D008012), Ca2+ (-), Na+ (MESH:D012964), ranolazine (MESH:D000069458), penicillin (MESH:D010406), streptomycin (MESH:D013307), ethanol (MESH:D000431), TTX (MESH:D013779), CO2 (MESH:D002245), MTT (MESH:C070243), Tetracaine (MESH:D013748)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** MDA-MB-231 — Homo sapiens (Human), Breast adenocarcinoma, Cancer cell line (CVCL_0062), SH-EP — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_0524), SK-N-BE — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_0528), NB-1 — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_S099), SK-N-SH — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_0531), KELLY — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_2092), IMR-5 — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_1306), SH-SY5Y — Homo sapiens (Human), Neuroblastoma, Cancer cell line (CVCL_0019)

## Full text

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## Figures

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## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC12862243/full.md

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Source: https://tomesphere.com/paper/PMC12862243