# Research progress on the role of MZB1 in immune regulation

## TL;DR

MZB1 is an important protein in immune regulation, affecting cell functions and disease processes, and could be a target for therapies.

## Contribution

This review synthesizes current knowledge on MZB1's roles in immune cells and its potential as a therapeutic target.

## Key findings

- MZB1 influences immune cell differentiation and antibody production.
- It plays a role in tumor biology and autoimmune diseases.
- MZB1 interacts with other immune regulatory factors in the microenvironment.

## Abstract

MZB1 (Marginal Zone B and B1 Cell-Specific Protein), an endoplasmic reticulum-resident protein, has recently garnered significant attention for its role in immune regulation. As a critical modulator within various immune cells, MZB1 influences key processes such as cell differentiation, antibody production, and immune microenvironment dynamics. Despite advances in understanding, the precise mechanisms by which MZB1 contributes to immune homeostasis and dysregulation in pathological conditions remain incompletely defined. Emerging evidence highlights its involvement in tumor biology, inflammatory responses, and autoimmune diseases, positioning MZB1 as a potential therapeutic target. This review aims to synthesize current research findings on MZB1’s functions across different immune cell types, elucidate its interactions with other immune regulatory factors, and explore its impact on the tumor microenvironment and immune-mediated disorders.