# Frailty and deconditioning on the acute take

**Authors:** Bhagya Arun, Siobhan H.M. Lewis

PMC · DOI: 10.1016/j.clinme.2025.100548 · Clinical Medicine · 2026-01-05

## TL;DR

Hospital deconditioning in older patients happens quickly and leads to issues like delirium and falls, requiring early intervention and care strategies.

## Contribution

Highlights the rapid onset of deconditioning in hospitals and emphasizes a team-wide approach to prevent it.

## Key findings

- Deconditioning can occur within hours of hospital admission, not just from prolonged stays.
- It is linked to delirium, falls, and healthcare-associated infections.
- Preventing deconditioning requires early mobility, proper nutrition, and care coordination.

## Abstract

•Deconditioning occurs rapidly upon arrival into hospital.•It is associated with delirium, falls, and healthcareassociated infection.•Promoting early safe mobility is essential.•Nutrition, hydration, comfort and sleep should be prioritised.•Deconditioning is everyone’s business, not just frailty teams.

Deconditioning occurs rapidly upon arrival into hospital.

It is associated with delirium, falls, and healthcareassociated infection.

Promoting early safe mobility is essential.

Nutrition, hydration, comfort and sleep should be prioritised.

Deconditioning is everyone’s business, not just frailty teams.

It is well known that older patients have a higher incidence of adverse hospital outcomes, such as inpatient falls, delirium and longer lengths of stay, and that older people are likely to become deconditioned during their time in hospital. It is often felt that deconditioning occurs as a consequence of a prolonged stay; however, the adverse effects of immobility can occur within hours of arrival into urgent care. Hospital-aquired deconditioning is in fact a multi-systemic syndrome that manifests in a number of ways outside muscle weakness, including delirium, healthcare-associated infection, new incontinence and falls, all of which can worsen outcomes for patients and lead to prolonged hospital stays. We outline strategies to embed preventing deconditioning into the care of older patients who present to the emergency and acute medical unit in order to avoid unnecessary harm and support patients to maintain their independence.

Image, graphical abstract

## Linked entities

- **Diseases:** delirium (MONDO:0045057), healthcare-associated infection (MONDO:0043544)

## Full-text entities

- **Diseases:** infection (MESH:D007239), delirium (MESH:D003693), Frailty (MESH:D000073496), incontinence (MESH:D014549), muscle weakness (MESH:D018908), falls (MESH:C537863)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12861237/full.md

## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12861237/full.md

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Source: https://tomesphere.com/paper/PMC12861237