# Can probiotic-rich yogurt help prevent colorectal cancer in humans?

**Authors:** Biplab Adhikari

PMC · DOI: 10.1016/j.cpt.2025.06.002 · Cancer Pathogenesis and Therapy · 2025-06-09

## TL;DR

Probiotic-rich yogurt may help reduce colorectal cancer risk by modulating gut bacteria and suppressing tumor growth.

## Contribution

The study highlights the role of Bifidobacterium in yogurt in suppressing tumor growth through immune and signaling pathways.

## Key findings

- Yogurt consumption is linked to a 20–40% lower colorectal cancer risk.
- Bifidobacterium strains in yogurt suppress tumor growth via immune pathway regulation.
- Probiotic therapy may reduce treatment side effects and improve quality of life.

## Abstract

•Yogurt consumption is linked to 20–40% lower colorectal cancer risk, especially proximal colon tumors with high Bifidobacterium levels.•Probiotics modulate gut microbiota, reduce inflammation, and produce protective metabolites against cancer development.•Bifidobacterium strains in yogurt suppress tumor growth through various signaling and immune pathway regulation.•Early screening age reduction and increased fiber intake are recommended for enhanced colorectal cancer prevention.•Probiotic therapy shows promise for reducing treatment side effects and improving patient quality of life.

Yogurt consumption is linked to 20–40% lower colorectal cancer risk, especially proximal colon tumors with high Bifidobacterium levels.

Probiotics modulate gut microbiota, reduce inflammation, and produce protective metabolites against cancer development.

Bifidobacterium strains in yogurt suppress tumor growth through various signaling and immune pathway regulation.

Early screening age reduction and increased fiber intake are recommended for enhanced colorectal cancer prevention.

Probiotic therapy shows promise for reducing treatment side effects and improving patient quality of life.

## Linked entities

- **Diseases:** colorectal cancer (MONDO:0005575)

## Full-text entities

- **Diseases:** colon tumors (MESH:D003110), cancer (MESH:D009369), inflammation (MESH:D007249), colorectal cancer (MESH:D015179)
- **Species:** Bifidobacterium (genus) [taxon 1678], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12861193/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12861193/full.md

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Source: https://tomesphere.com/paper/PMC12861193