# Self‐help group participation, avoidance of nonalcoholic beer, and nonsmoking independently predict better drinking outcomes in Japanese alcohol‐dependent men

**Authors:** Akira Yokoyama, Mitsuru Kimura, Atsushi Yoshimura, Junichi Yoneda, Hitoshi Maesato, Yasunobu Komoto, Hideki Nakayama, Hiroshi Sakuma, Yosuke Yumoto, Tsuyoshi Takimura, Tomomi Toyama, Takeshi Mizukami, Tetsuji Yokoyama, Susumu Higuchi, Sachio Matsushita

PMC · DOI: 10.1111/acer.70227 · Alcohol, Clinical & Experimental Research · 2026-02-01

## TL;DR

Japanese men recovering from alcohol dependence who joined self-help groups, avoided nonalcoholic beer, and didn't smoke had better long-term sobriety outcomes.

## Contribution

Identified three modifiable behaviors with a dose-response pattern that significantly predict better drinking outcomes in alcohol-dependent men.

## Key findings

- Self-help group participation was associated with a 52.7% one-year abstinence rate compared to 36.8% for nonparticipants.
- Nonalcoholic beer use increased the risk of drinking lapses (HR 2.30) while avoiding it improved abstinence rates.
- Combining self-help, no nonalcoholic beer, and nonsmoking provided the strongest protection against relapse (HR 0.14).

## Abstract

Relapse after inpatient treatment for alcohol dependence is a major barrier to recovery. This study evaluated one‐year drinking outcomes and their associations with self‐help group participation, nonalcoholic beer use, smoking after discharge, and other prognostic factors among Japanese men treated for alcohol dependence.

We conducted a prospective 12‐month follow‐up of 198 male patients who completed a three‐month inpatient program in 2014. Drinking status, self‐help participation, nonalcoholic beer consumption, and smoking after discharge were assessed by mailed questionnaires. Time to first drink, heavy‐drinking lapse, and sustained relapse were analyzed using Kaplan–Meier estimates and multivariate Cox proportional hazards models.

One‐year abstinence was higher among self‐help participants (n = 51) than nonparticipants (n = 147) (52.7% vs. 36.8%, p = 0.019) and higher among nonusers (n = 143) than users of nonalcoholic beer (n = 55) (51.2% vs. 15.3%, p < 0.0001). In multivariate models, self‐help participation reduced the risk of a drinking lapse (HR 0.51, 95% CI 0.31–0.82) and use of nonalcoholic beer increased the risk (HR 2.30, 95% CI 1.54–3.44). Smoking within one month after discharge, a family history of heavy or problem drinking, and use of psychiatric medication at discharge were also associated with higher hazards. Sensitivity analyses treating dropouts as lapses did not change the results. Heavy‐drinking‐free rates and sustained‐relapse‐free rates followed similar patterns. A dose–response pattern emerged: Having all three modifiable protective behaviors (self‐help participation, no nonalcoholic beer, and nonsmoking) offered the strongest protection against lapse and relapse [drinking lapse HR 0.18 (95% CI 0.06–0.50); heavy‐drinking lapse HR 0.13 (95% CI 0.04–0.48); sustained relapse HR 0.14 (95% CI 0.04–0.48)], two factors showed intermediate protection, and a single factor alone was not significant.

Strengthening self‐help participation and smoking cessation support at discharge is recommended, and caution is warranted regarding nonalcoholic beer as a potential jeopardy to abstinence.

This prospective study of 198 Japanese men found that one‐year abstinence after inpatient alcohol treatment was significantly higher among those who joined self‐help groups, avoided nonalcoholic beer, and did not resume smoking. A clear dose–response pattern showed that combining all three behaviors offered the strongest protection against relapse. These findings highlight the importance of postdischarge behavioral support and caution against nonalcoholic beer use, suggesting that targeted interventions could enhance long‐term recovery outcomes in alcohol dependence treatment.

## Linked entities

- **Diseases:** alcohol dependence (MONDO:0002046)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** psychotic disorder (MESH:D011618), antisocial personality disorder (MESH:D000987), anxiety disorder (MESH:D001008), death (MESH:D003643), overdose (MESH:D062787), Drinking lapse (MESH:D063425), affective disorder (MESH:D019964), insomnia (MESH:D007319), AD (MESH:D000437), eating disorder (MESH:D001068), Neurological and Psychiatric Disorders (MESH:D001523), addiction (MESH:D019966)
- **Chemicals:** ethanol (MESH:D000431), disulfiram (MESH:D004221), acamprosate (MESH:D000077443), benzodiazepine (MESH:D001569), varenicline (MESH:D000068580), Alcohol (MESH:D000438), sleeping drugs (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

36 references — full list in the complete paper: https://tomesphere.com/paper/PMC12861170/full.md

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Source: https://tomesphere.com/paper/PMC12861170