# Light and myopia: a focus on the expanding role of non-visual opsins

## TL;DR

This paper reviews how non-visual opsins may influence myopia and could lead to new treatment strategies.

## Contribution

The paper highlights the emerging role of non-visual opsins in myopia regulation and their potential for future treatments.

## Key findings

- Non-visual opsins OPN3, OPN4, and OPN5 are potentially involved in regulating myopia.
- Current understanding of non-visual opsins could inform new treatment strategies for myopia.

## Abstract

Myopia, or near-sightedness, is a growing global concern as its incidence rate continues to dramatically rise. It has been linked to significant ocular morbidity and reduced quality of life. Despite this, much is still largely unknown about the development of and the mechanisms driving the pathogenesis of myopia. As such, myopia prevention and myopia mitigation treatment strategies are occasionally ineffective, can be difficult to adhere to, and have diminishing returns over time. Recently, non-visual opsins (OPN3, OPN4, and OPN5) have emerged as potentially impacting myopia regulation. This narrative review aims to summarize the current understanding of the non-visual opsins and how they might influence myopia. In addition, this review explores how utilizing this knowledge can help develop promising future treatment strategies to reduce the incidence and severity of myopia.