# Renal Sarcoidosis Presenting as Acute Kidney Injury With Persistent Hypercalcemia in the Absence of Respiratory Symptoms: A Report of a Rare Case

**Authors:** Muhammad J Khan, Muhammad Ali Akbar, Toqeer Ahmad, Aliza Zahid, Farhan Faisal

PMC · DOI: 10.7759/cureus.100591 · Cureus · 2026-01-01

## TL;DR

A rare case of kidney sarcoidosis is reported, presenting with sudden kidney failure and high calcium levels without lung symptoms.

## Contribution

Highlights a rare presentation of renal sarcoidosis without respiratory symptoms, emphasizing diagnostic challenges.

## Key findings

- Patient presented with acute kidney injury and hypercalcemia without respiratory symptoms.
- Diagnosis of renal sarcoidosis was confirmed after thorough evaluation.
- Early recognition improved patient outcomes through timely treatment.

## Abstract

Sarcoidosis is a chronic multisystem granulomatous disease of unknown etiology, known for its diverse manifestations and ability to mimic other pathologies. Renal involvement in sarcoidosis is uncommon.

We present a diagnostically challenging case of a 66-year-old male who presented with unintentional weight loss, anorexia, and lethargy, having acute kidney injury (AKI) and refractory hypercalcemia, ultimately diagnosed with renal sarcoidosis. This report underscores the significance of maintaining a broad differential diagnosis in cases of unexplained AKI and hypercalcemia, especially in the absence of respiratory symptoms.

Early recognition of key imaging and biochemical clues allows prompt initiation of therapy and helps optimize patient outcomes.

## Linked entities

- **Diseases:** sarcoidosis (MONDO:0008399), acute kidney injury (MONDO:0002492), hypercalcemia (MONDO:0001566)

## Full-text entities

- **Diseases:** anorexia (MESH:D000855), weight loss (MESH:D015431), granulomatous disease (MESH:D006105), Hypercalcemia (MESH:D006934), lethargy (MESH:D053609), AKI (MESH:D058186), Renal involvement (MESH:C565423), Renal Sarcoidosis (MESH:D012507)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12860891/full.md

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Source: https://tomesphere.com/paper/PMC12860891