# A Concurrent Finding of Pulmonary Sarcoidosis, Primary Hyperparathyroidism, Thyroid Nodules, and Adrenal Tumor in a Sexagenarian

**Authors:** Alamin Alkundi, Rabiu Momoh

PMC · DOI: 10.7759/cureus.100549 · 2026-01-01

## TL;DR

A 60-year-old patient had four rare health conditions at once, prompting a study of their possible connections.

## Contribution

The paper reports a rare case of co-occurring pulmonary sarcoidosis, primary hyperparathyroidism, thyroid nodules, and adrenal tumor.

## Key findings

- The patient had pulmonary sarcoidosis, primary hyperparathyroidism, thyroid nodules, and adrenal tumor simultaneously.
- The authors explored potential pathophysiological links among these coexisting conditions.
- The case highlights the complexity of managing multiple rare diseases in a single patient.

## Abstract

The concurrent presence of pulmonary sarcoidosis, primary hyperparathyroidism (PHPT), thyroid nodules, and adrenal tumor in an individual or patient is rare and complex. We present a rare scenario of the presence of the above conditions in a 60-year-old hypertensive patient (with a high plasma aldosterone-to-renin ratio) who was followed up in an endocrinology clinic at a district general hospital. We have reviewed the literature in a bid to offer insights into possible pathophysiological connections and underlying mechanisms to account for this.

## Linked entities

- **Diseases:** pulmonary sarcoidosis (MONDO:0001708), primary hyperparathyroidism (MONDO:0010837), adrenal tumor (MONDO:0021227)

## Full-text entities

- **Genes:** REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}
- **Diseases:** Thyroid Nodules (MESH:D016606), hypertensive (MESH:D006973), Pulmonary Sarcoidosis (MESH:D017565), Adrenal Tumor (MESH:D000310), PHPT (MESH:D049950)
- **Chemicals:** aldosterone (MESH:D000450)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12860564/full.md

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Source: https://tomesphere.com/paper/PMC12860564