# Evaluation of the Relationship Between Isometric Exercise and Roll‐Over Tests and the Levels of Pregnancy‐Associated Plasma Protein A and Beta‐Human Chorionic Gonadotropin and Neutrophil–Lymphocyte Ratio in the Early Diagnosis of Preeclampsia

## TL;DR

This study explores how isometric exercise and roll-over tests, along with specific protein and cell ratio levels, can help detect preeclampsia early in pregnancy.

## Contribution

The study introduces the use of isometric exercise and roll-over tests as novel diagnostic tools for early preeclampsia detection.

## Key findings

- Roll-over and isometric exercise tests showed high sensitivity and specificity for preeclampsia diagnosis.
- PAPP-A levels and neutrophil–lymphocyte ratio are useful in early preeclampsia detection.
- Combining tests and biomarkers improves early diagnostic accuracy for preeclampsia.

## Abstract

This study aimed to determine the relationship between isometric exercise test, roll‐over test, levels of PAPP‐A and β‐hCG, and NLO in the early diagnosis of preeclampsia.

The 580 pregnant women filled out the personal information forms and performed the roll‐over test and isometric exercise test.

The roll‐over test and isometric exercise test used in the diagnosis of preeclampsia had high levels of sensitivity and specificity and negative predictive values.

Thus, roll‐over test and isometric exercise test, pregnancy‐associated plasma protein A levels, and neutrophil–lymphocyte ratio are useful parameters for the early diagnosis of preeclampsia.