Synthesis, Topological, and Biological Studies of a Novel One‐Dimensional Hg(II) Coordination Polymer With Antibacterial and Anticancer Potentials
Shekufeh Alaei, Khosro Mohammadi, Payam Hayati, Somayyeh Gharibi, Arezoo Khoradmehr, Zeinab Asen, Jan Janczak, Eugeny V. Alexandrov
TL;DR
A new mercury-based coordination polymer was created and shown to have antibacterial and anticancer properties.
Contribution
The synthesis and characterization of a novel one-dimensional mercury coordination polymer with antibacterial and anticancer potentials.
Findings
The coordination polymer exhibits antibacterial activity comparable to standard antibiotics.
It shows selective anticancer activity by destroying cancer cells while preserving normal cells.
The structure features two types of mercury centers with distinct coordination geometries.
Abstract
A novel one‐dimensional mercury coordination polymer (CP), identified as [(μ2‐Cl)(Ina)Hg(μ3‐Cl)Hg(μ2‐Cl)2(Ina)]n (1) (where Ina represents isonicotinic acid or 4‐pyridinecarboxylic acid), was synthesized via the interaction of isonicotinic acid with mercury(II) salt. This synthesis was achieved through two distinct experimental approaches: layering methods for the formation of single crystals (1) and sonochemical irradiation for the production of nanostructures (1′). The structural characterization of (1) was performed using X‐ray diffraction and crystallography techniques. Further characterization involved a range of methods, including X‐ray powder diffraction (XRD), infrared (IR) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and Hirshfeld surface analysis (HSA). The CP of (1) features two types of metal centers, exhibiting coordination numbers of…
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Taxonomy
TopicsMetal-Organic Frameworks: Synthesis and Applications · Crystal structures of chemical compounds · Organometallic Compounds Synthesis and Characterization