Harnessing nanozymes as next-generation antimicrobial agents: From mechanisms to therapeutic strategies
Shanshan Feng, Zhaoxun Wang, Yibin Zhang, Ling Mei, Zhenxing Wang
TL;DR
Nanozymes, nanomaterials that mimic enzymes, show promise as new antimicrobial agents due to their broad activity and unique mechanisms against drug-resistant pathogens.
Contribution
This review introduces nanozymes as a novel class of antimicrobial agents with resistance-independent mechanisms and broad-spectrum efficacy.
Findings
Nanozymes can generate reactive oxygen species and disrupt biofilms to combat infections.
They demonstrate effectiveness across various infection models, including skin, oral, and systemic infections.
Challenges remain in clinical translation, including biosafety and scalable production.
Abstract
The escalating threat of antimicrobial resistance (AMR) and the limited efficacy of conventional antibiotics have intensified the search for alternative therapeutic strategies. Nanozymes, nanomaterials with enzyme-mimicking properties, have emerged as a promising class of antimicrobial agents due to their broad-spectrum activity, tunable catalytic functions, and resistance-independent mechanisms. This review provides a comprehensive overview of the recent advances in nanozyme-based antimicrobial applications, focusing on their classification, catalytic mechanisms, and multifaceted antimicrobial actions. We highlight the unique advantages of nanozymes, including their ability to generate reactive oxygen species (ROS), disrupt biofilms, modulate infection microenvironments, and synergize with other therapeutic modalities. Furthermore, we discuss their performance in various infection…
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Taxonomy
TopicsAdvanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications