Comparative study on salivary IL- 8 and LDH among tobacco users without lesions, leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma

TL;DR

This study compares salivary IL-8 and LDH levels in tobacco users with and without oral conditions to identify potential biomarkers for early cancer detection.

Contribution

The study identifies salivary IL-8 and LDH as potential biomarkers for early detection of oral squamous cell carcinoma.

Findings

Salivary IL-8 and LDH levels increase with the progression of oral diseases.

These biomarkers could aid in the early detection of OSCC and prognosis of OPMDs.

Abstract

Oral and oropharyngeal malignancies, OSCC accounts for 95% of cases. Diagnosis and prognosis of OSCC relies upon the tumour staging,
an important predictor of survival. Therefore, it is of interest to evaluate the changes in the salivary levels of IL-8 and LDH among
Tobacco users without lesions, Individuals with Leukoplakia, Oral submucous fibrosis and OSCC. 40 cases were analysed in this study. We
show that salivary IL8 and LDH which can serve as one reliable biomarker in early detection of OSCC and a prognostic indicator for
OPMDs.