Prevalence and risk factors for drug-induced cutaneous reactions among hospitalised patients: A retrospective study

TL;DR

This study examines how often skin reactions caused by medications occur in hospitalized patients and identifies risk factors like age and medication history.

Contribution

The study identifies key risk factors and common medication classes linked to drug-induced skin reactions in hospitalized patients.

Findings

Maculopapular rashes were the most common type of drug-induced skin reaction observed.

Antibiotics and anticonvulsants were the medication classes most frequently associated with skin reactions.

Advanced age, polypharmacy, and a history of medication allergies were significant risk factors.

Abstract

One of the most frequent adverse medication events seen in hospitalized patients is drug-induced cutaneous response (DICR). Hence,
143 inpatients that experienced dermatological symptoms as a result of pharmaceutical treatment were assessed in this retrospective
investigation. Maculopapular rashes were the most common appearance and the two main medication classes implicated were antibiotics and
anticonvulsants. There were notable correlations seen with advanced age, polypharmacy and a history of medication allergies. Early
detection of high-risk profiles can improve patient safety and pharmacovigilance.