# Sleep deprivation as a risk factor for cognitive decline among middle-aged adults

**Authors:** Debadrit Biswas, Pooja Saithya Pillarisetti, Achyuth Prasad Jakka, Subash Kumar

PMC · DOI: 10.6026/973206300213484 · 2025-10-31

## TL;DR

This study shows that not getting enough sleep over three years is linked to faster cognitive decline in middle-aged adults.

## Contribution

The study identifies chronic sleep deprivation as an independent predictor of cognitive decline in middle-aged adults.

## Key findings

- Individuals sleeping less than 6 hours per night showed significant declines in memory and attention.
- The association remained significant after adjusting for age, sex, and comorbidities.

## Abstract

The impact of chronic sleep deprivation on cognitive decline among 140 middle-aged adults aged 40-60 years over a 3-year period is of
interest. Participants were assessed using standardized cognitive batteries and sleep tracking devices. Data revealed that individuals
sleeping less than 6 hours per night had significantly greater declines in memory, executive function and attention. These associations
remained significant after adjusting for confounders such as age, sex and comorbidities. Chronic insufficient sleep appears to be an
independent predictor of accelerated cognitive decline.

## Full-text entities

- **Diseases:** cognitive decline (MESH:D003072), Chronic insufficient sleep (MESH:D012892)

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Source: https://tomesphere.com/paper/PMC12859356