A randomized comparative study on successional versus premixed intrathecal administration of hyperbaric ropivacaine 0.75% and fentanyl in elective urological surgery

TL;DR

This study compares two methods of administering drugs for spinal anesthesia during urological surgery, finding that one method offers faster and longer-lasting effects with stable blood pressure.

Contribution

The study introduces successional administration as a novel method for spinal anesthesia with improved outcomes.

Findings

Successional administration led to earlier onset and longer duration of sensory and motor blocks.

Hemodynamics were more stable with successional administration.

Both methods had comparable side effects.

Abstract

The effects of successional versus premixed administration of fentanyl and hyperbaric ropivacaine for urological surgeries is of
interest. Hence, a total of 56 patients were randomized into two groups: Group P received a premixed solution and Group S received
fentanyl followed by ropivacaine. Results showed that Group S had an earlier onset and longer duration of sensory and motor blocks, with
more stable hemodynamics. Side effects were comparable between the two groups. Thus, we show that successional administration provides
faster onset, prolonged block duration and better hemodynamic stability with minimal side effects.