# AI-assisted diagnosis of anemia through peripheral smear image analysis: A cross-validation study

**Authors:** Ashita Nain, Sangeeta Gupta, Sylvester Noeldoss Lazarus, Kawalinder Kaur Girgla, Parth Jani, Amrit Podder, Sreemoyee Dutta, Ravi Babu Surisetti

PMC · DOI: 10.6026/973206300213668 · 2025-10-31

## TL;DR

This paper presents an AI model that accurately detects and classifies anemia from blood smear images, showing strong agreement with expert diagnoses.

## Contribution

A deep semi-supervised learning model for anemia diagnosis using only 25% annotated data, achieving high accuracy and F1-scores.

## Key findings

- The model achieved 93.4% classification accuracy and F1-scores above 90% for key anemia subtypes.
- It showed strong agreement with expert diagnoses (κ = 0.89) and performed well in detecting microcytic and sickle cell anemia.
- The model significantly reduced diagnostic time and is suitable for resource-limited settings.

## Abstract

A deep semi-supervised learning model for automating anemia detection and classification from peripheral blood smear images is of
interest. A convolutional neural network was trained on 3,200 images, with only 25% annotated by expert hematologists. The model
achieved a classification accuracy of 93.4% and F1-scores above 90% for key anemia subtypes, demonstrating strong agreement with expert
diagnoses (κ = 0.89). It significantly reduced diagnostic time and performed well in detecting microcytic and sickle cell anemia.
This AI-based framework shows great potential for accurate anemia diagnosis, especially in resource-limited settings.

## Linked entities

- **Diseases:** anemia (MONDO:0002280), microcytic anemia (MONDO:0001245), sickle cell anemia (MONDO:0011382)

## Full-text entities

- **Diseases:** microcytic (MESH:C536357), anemia (MESH:D000740), sickle cell anemia (MESH:D000755)

---
Source: https://tomesphere.com/paper/PMC12859316