# Analytical cohort study on cognitive reserve as a predictor of post-stroke dementia severity

**Authors:** Shreya Krishna, Subash Kumar, Elakkiya L., Shanmukha Koppolu, Shabrin Abdul Rasheed, Vijaya Madhuri Devi Kunche, Ayush Bhardwaj

PMC · DOI: 10.6026/973206300213480 · 2025-10-31

## TL;DR

This study shows that higher cognitive reserve, measured through education and mental activities, helps reduce dementia severity after stroke in older adults.

## Contribution

The study demonstrates cognitive reserve as a significant protective factor against severe post-stroke dementia.

## Key findings

- Higher cognitive reserve scores were linked to milder dementia outcomes after stroke.
- Individuals with higher cognitive reserve showed better functional independence post-stroke.

## Abstract

The role of cognitive reserve in determining the severity of dementia following a stroke in individuals aged 55 and above is of
interest. Hence, a total of 128 stroke survivors were followed for 12 months post-event, with cognitive reserve quantified using
education level, occupational attainment and engagement in cognitive activities. Higher cognitive reserve scores were associated with
milder post-stroke dementia outcomes and better functional independence. Thus, we show that cognitive reserve is a significant protective
factor against severe cognitive decline after stroke.

## Linked entities

- **Diseases:** dementia (MONDO:0001627), stroke (MONDO:0005098)

## Full-text entities

- **Diseases:** cognitive decline (MESH:D003072), dementia (MESH:D003704), post-stroke (MESH:D020521)

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Source: https://tomesphere.com/paper/PMC12859309