# Role of AI in the analysis of total knee arthroplasty

**Authors:** Anuraag Mohanty, Priyankar Nanda, Preethiv Rajendran

PMC · DOI: 10.6026/973206300213725 · 2025-10-31

## TL;DR

This study evaluated an AI model's ability to predict outcomes and infection risk in knee replacement surgery, finding it moderately accurate but needing improvement.

## Contribution

A ChatGPT-based AI model was tested for predicting 1-year outcomes and infection risk in total knee arthroplasty patients.

## Key findings

- The AI model underpredicted KOOS scores by 7-8 points compared to surgeon-reported outcomes.
- The model's predicted infection risk was slightly higher than the observed rate with an ROC-AUC of 0.70.
- The model showed moderate correlation (r = 0.45) with actual outcomes but requires fine-tuning for clinical use.

## Abstract

This retrospective cohort assessed a ChatGPT-based AI model for 1-year KOOS prediction and infection risk in 98 primary total knee
replacement (TKR) patients. The model predicted based on preoperative clinical, demographic, and intra-operative data. The model under
predicted the mean knee injury and osteoarthritis Outcome Score (KOOS) by 7-8 points compared to surgeon-reported outcomes (p = 0.02)
with moderate correlation (r = 0.45).Predicted risk of infection (2.4%) was nominally higher than observed (1.8%), with an ROC-AUC of
0.70. Directionally accurate, the model requires further fine-tuning prior to clinic use.

## Linked entities

- **Diseases:** osteoarthritis (MONDO:0005178)

## Full-text entities

- **Diseases:** osteoarthritis (MESH:D010003), infection (MESH:D007239), knee injury (MESH:D007718)
- **Species:** Homo sapiens (human, species) [taxon 9606]

---
Source: https://tomesphere.com/paper/PMC12859300