# Sonoelastography in differentiating benign and malignant thyroid nodules: A histopathological correlation

**Authors:** Md Shahrukh Ansari, Suresh Kumar Toppo, Rajeev Kumar Ranjan, Anima Ranjni Xalxo, Sonali Priyadarsini Reddy, Soumik Pal, Riya Agarwal, Sumaiya Shikoh

PMC · DOI: 10.6026/973206300213744 · 2025-10-31

## TL;DR

This study shows that sonoelastography can help tell the difference between benign and malignant thyroid nodules, potentially reducing the need for biopsies.

## Contribution

The study introduces a new cutoff value for ARFI imaging to improve thyroid nodule classification accuracy.

## Key findings

- Malignant thyroid nodules had significantly higher ARFI values than benign ones.
- Using a 2.8 m/s cutoff, ARFI achieved high sensitivity and specificity in differentiating nodules.
- Combining ARFI with conventional ultrasound improved diagnostic accuracy.

## Abstract

Thyroid nodules are common and distinguishing benign from malignant ones is essential for optimal management. This cross-sectional
study of 120 patients assessed Acoustic Radiation Force Impulse (ARFI) imaging in differentiating thyroid nodules, correlating results
with histopathology. Malignant nodules showed higher mean ARFI values (3.59 ± 0.7 m/s) than benign ones (1.98 ± 0.31 m/s).
With a 2.8 m/s cutoff, ARFI achieved 92.6% sensitivity and 92.9% specificity. Combining ARFI with conventional ultrasound improved
diagnostic accuracy, highlighting its potential to reduce unnecessary biopsies.

## Full-text entities

- **Diseases:** Thyroid nodules (MESH:D016606)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12859297