Assessing healing of periapical pathologies by platelet-rich fibrin: A clinical study

TL;DR

This study shows that using platelet-rich fibrin improves healing after dental surgery for bone and soft tissue repair.

Contribution

The study demonstrates PRF's effectiveness in enhancing bone regeneration and reducing post-operative pain.

Findings

PRF showed 85.2% bone regeneration compared to 64.8% with natural healing.

PRF reduced post-operative discomfort on days 1 and 3.

PRF is an inexpensive and practical method for improving surgical recovery.

Abstract

One of the on-going clinical challenges in endodontic microsurgery is the regeneration of massive periapical lesions. Hence, a Forty
patients participated in this randomized controlled clinical experiment to see how well platelet-rich fibrin (PRF) worked as a scaffold
for regeneration in comparison to the body's inherent ability to mend blood clots. The decrease in lesion volume, pain ratings, and the
repair of soft tissues were evaluated at 6 and 12 months by CBCT. PRF demonstrated a much higher rate of bone regeneration (85.2% vs.
64.8%, p < 0.001) and reduced levels of post-operative discomfort on days 1 and 3. Thus, we show that PRF is an inexpensive and easy
way to improve the predictability of recovery after periapical surgery.