# Transient diabetes insipidus in post CABG patient after vasopressin withdrawal: A report

**Authors:** Mukesh Kumar Jaswant Singh Pachahara, Rajat Kalra, Ravi Roshan, Hirday Kumar

PMC · DOI: 10.6026/973206300213564 · 2025-10-31

## TL;DR

A patient developed transient diabetes insipidus after stopping vasopressin following heart surgery.

## Contribution

This report highlights a rare case of DI caused by vasopressin withdrawal after CABG.

## Key findings

- Diabetes insipidus occurred after vasopressin was discontinued post-CABG.
- The case suggests a possible link between vasopressin withdrawal and DI.
- The condition was transient and resolved with appropriate management.

## Abstract

Vasopressin is increasingly being used as inotropic agent due to its catecholamine's sparing property. Vasopressin is instrumental in
rapid adjustment of water excretion according to the state of body hydration. It is also used in treatment of DI; Arginine vasopressin
disorder, formerly known as diabetes insipidus (DI), is a disease process that results in either decreased release of antidiuretic
hormone (Anti Diuretic Hormone (ADH), also known as vasopressin or Arginine Vasopressin (AVP) or reduced response to ADH, causing
electrolyte imbalances. however, there are only anecdote reports discussing the precipitation of DI d/t vasopressin withdrawal. Hence,
we report a case of diabetes insipidus in post Coronary artery bypass grafting after vasopressin withdrawal.

## Linked entities

- **Chemicals:** vasopressin (PubChem CID 8230), Arginine vasopressin (PubChem CID 644077), Arginine Vasopressin (PubChem CID 644077)
- **Diseases:** diabetes insipidus (MONDO:0004782)

## Full-text entities

- **Genes:** AVP (arginine vasopressin) [NCBI Gene 551] {aka ADH, ARVP, AVP-NPII, AVRP, VP}
- **Diseases:** DI (MESH:D003919), Arginine vasopressin disorder (MESH:D020790)
- **Chemicals:** d/ (MESH:D003903), water (MESH:D014867), catecholamine (MESH:D002395)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12859288