# Combined HIF-1α blockade and CHIR99021 treatment reverses pulmonary fibrosis via modulation endothelial-to-mesenchymal transition

**Authors:** Jae-Kyung Nam, Seo-Hyun Choi, Ji-Hee Kim, Kyu Jin Choi, Hae-June Lee, Jeeyong Lee, Haeng Ran Seo, Yoon-Jin Lee

PMC · DOI: 10.1016/j.isci.2026.114722 · 2026-01-22

## Full-text entities

- **Genes:** HIF1A (hypoxia inducible factor 1 subunit alpha) [NCBI Gene 3091] {aka HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1}
- **Diseases:** pulmonary fibrosis (MESH:D011658)
- **Chemicals:** CHIR99021 (MESH:C473711)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12859198/full.md

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Source: https://tomesphere.com/paper/PMC12859198