Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions
Maryam Anwar, Moumita Sarkar, Kerrie Ford, Gianni D. Angelini, Prakash P. Punjabi, Yingshu Guan, Abas Laftah, Aránzazu Chamorro-Jorganes, Jiahui Ji, Prashant K. Srivastava, Enrico Petretto, Costanza Emanueli
TL;DR
This study identifies a new RNA network in heart disease and diabetes that could help develop treatments to improve blood vessel growth.
Contribution
The study reveals a novel proangiogenic role for circNPHP1 in cardiac endothelial cells under ischemic and diabetic conditions.
Findings
CircNPHP1 promotes angiogenesis by sponging miR-221-3p in ischemic and diabetic conditions.
The circNPHP1-miR-221-3p-BCL2-VEGFA subnetwork is involved in endothelial cell proliferation and angiogenesis.
CircNPHP1 is identified as a potential therapeutic target for promoting blood vessel growth in heart disease.
Abstract
•We found a novel circRNA-miRNA-mRNA network in IHD and T2DM.•CircNPHP1 regulates angiogenesis and proliferation in the cardiac endothelial cells exposed to conditions mimicking IHD and T2DM.•We elucidated a novel proangiogenic subnetwork consisting of circNPHP1, miR-221-3p, BCL2, and VEGFA.•We identified circNPHP1 as a potential new target for therapeutic angiogenesis. We found a novel circRNA-miRNA-mRNA network in IHD and T2DM. CircNPHP1 regulates angiogenesis and proliferation in the cardiac endothelial cells exposed to conditions mimicking IHD and T2DM. We elucidated a novel proangiogenic subnetwork consisting of circNPHP1, miR-221-3p, BCL2, and VEGFA. We identified circNPHP1 as a potential new target for therapeutic angiogenesis. Therapies promoting microvascular flow and endothelial repair require effective identification of new targets in ischemic heart disease (IHD). The…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsCircular RNAs in diseases · MicroRNA in disease regulation · Cardiovascular Disease and Adiposity