Potential Anti‐Aging Effects of a Dietary Supplement From the Algal‐Derived Omega‐3 DHA in Aged SAMP 8 Mice

TL;DR

Algal Omega-3 DHA supplementation in aged mice improved cognitive function, reduced aging markers, and extended lifespan without adverse effects.

Contribution

This study demonstrates the anti-aging and neuroprotective effects of algal-derived Omega-3 DHA in SAMP8 mice.

Findings

Algal Omega-3 DHA reduced brain aging markers like 8-OHdG, TBARS, and β-amyloid protein.

Supplementation improved cognitive performance and extended survival in both male and female mice.

Antioxidant enzyme activities in the liver increased in the phospholipid-supplemented groups.

Abstract

This study investigated the anti‐aging effects of algal Omega3‐DHA in senescence‐accelerated mice (SAM). Male and female SAMP8 mice (3 months old) were divided into a control group and four experimental groups (1× or 2× algal Omega3‐DHA, with/without phospholipids). The mice were orally administered test samples dissolved in corn oil daily for 13 weeks. Aging scores were significantly lower in male mice across all experimental groups and in female mice in the phosphatidylcholine (PC) and phosphatidylserine (PS) (p < 0.05) groups. Learning and memory improved significantly in all the experimental groups (p < 0.05). Brain biomarkers of aging, including 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), thiobarbituric acid‐reactive substances (TBARS), protein carbonyl content, and β‐amyloid (Aβ) protein, were significantly reduced, while liver antioxidant enzyme activities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were increased in the PC and PS groups (p < 0.05). Additionally, survival times were extended in both male and female mice compared to controls. No adverse effects were observed in terms of body weight or activity level. In summary, algal Omega3‐DHA supplementation improved cognitive performance, enhanced antioxidant defenses, reduced aging markers, and delayed aging in SAM mice, highlighting its potential as a promising anti‐aging strategy.

Algal‐derived Omega‐3 DHA supplementation exerts significant anti‐aging and neuroprotective effects in SAMP8 mice. Algal Omega‐3 DHA effectively mitigates age‐related cognitive decline, enhances antioxidant defenses, and extends lifespan. Algal‐derived Omega‐3 DHA supplementation enhances cognitive function, attenuates oxidative stress, and reduces neurodegenerative markers.

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