Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster
Vaibhav Tiwary, Nares Trakooljul, Shahaf Peleg
TL;DR
Reserpine extends the lifespan of fruit flies but reduces their movement and ability to survive heat stress.
Contribution
The study reveals a trade-off between lifespan extension and stress resilience with reserpine in Drosophila.
Findings
Reserpine extends Drosophila lifespan in a dose-dependent manner.
Reserpine-treated flies show reduced locomotion and impaired heat-stress survival.
Reserpine induces a low-energy state and blunts protective gene responses to heat stress.
Abstract
Pharmacological modulation of monoaminergic signaling, a process targeted by many therapeutic and recreational drugs via receptors, transporters, degradation enzymes, or reuptake mechanisms, is emerging as a promising aging intervention and as a strategy to treat various maladies. Monoamines (including dopamine, serotonin, and norepinephrine) are central to the regulation of mood, movement, sleep, memory, and systemic physiology. Here, we demonstrate that Reserpine, chronic inhibitor of the vesicular monoamine transporter (VMAT), robustly extends lifespan in Drosophila melanogaster in a dose-dependent manner. However, reserpine-treated flies also exhibit reduced locomotor activity and impaired survival under acute heat-stress, indicating a context-dependent trade-off between lifespan extension and stress resilience. Transcriptomic profiling revealed that reserpine induces a…
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Taxonomy
TopicsGenetics, Aging, and Longevity in Model Organisms · Neurobiology and Insect Physiology Research · Invertebrate Immune Response Mechanisms