# Müllerian adenosarcoma mimicking cervical carcinoma in a 79-year-old woman: diagnostic challenges and laparoscopic treatment: a case report

**Authors:** Fang Zhang, Jie Hu, Jia Bian, Yupeng Lan

PMC · DOI: 10.11604/pamj.2025.52.110.49172 · 2025-11-13

## TL;DR

A 79-year-old woman's cervical-like tumor was actually a rare uterine adenosarcoma, highlighting the importance of accurate diagnosis and surgical treatment.

## Contribution

This is the first detailed case report of Müllerian adenosarcoma presenting as a cervical cancer-like mass in an elderly woman.

## Key findings

- The tumor was initially misdiagnosed as advanced cervical carcinoma due to its appearance on imaging.
- Complete surgical excision led to a disease-free status at 7 months, confirming good outcomes for stage I adenosarcoma.
- WT1/ER immunohistochemistry was critical in determining the tumor's origin and guiding treatment.

## Abstract

Uterine Müllerian adenosarcoma rarely presents as a cervical “cancer-like” mass; we report the first detailed case in a 79-year-old woman whose 5-cm exophytic lesion mimicked advanced cervical carcinoma on imaging. She presented with 2 weeks of post-menopausal bleeding and a friable polyp protruding through the cervical os; MRI described a bulky cervical tumour extending into the lower uterine segment, while tumour markers remained normal. Initial biopsy was inconclusive; subsequent excision and hysterectomy revealed FIGO stage Ib1 low-grade adenosarcoma originating from the lower uterine segment with superficial cervical involvement. Laparoscopic total hysterectomy with bilateral salpingo-oophorectomy was performed uneventfully, and at 7 months she remains disease-free. The case underlines that adenosarcoma can masquerade as cervical cancer, emphasises the need for generous tissue sampling and WT1/ER-based immunohistochemistry to define tumour origin, and confirms excellent outcomes with complete surgical excision for stage I disease.

## Linked entities

- **Proteins:** WT1 (WT1 transcription factor), EREG (epiregulin)
- **Diseases:** adenosarcoma (MONDO:0005636), cervical carcinoma (MONDO:0005131)

## Full-text entities

- **Genes:** WT1 (WT1 transcription factor) [NCBI Gene 7490] {aka AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1}, EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}
- **Diseases:** polyp (MESH:D011127), Mullerian adenosarcoma (MESH:C538232), stage I disease (MESH:D007676), adenosarcoma (MESH:D018195), cervical cancer (MESH:D002583), bleeding (MESH:D006470), cancer (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12858637/full.md

---
Source: https://tomesphere.com/paper/PMC12858637