# Ulcerated necrobiosis lipoidica: clinical and histopathological presentation of two cases

**Authors:** Vitória Mariah Giriboni, Lucas Silva Cortes, Simone Antunes Terra, Luciana Patricia Fernandes Abbade

PMC · DOI: 10.1016/j.abd.2025.501279 · Anais Brasileiros de Dermatologia · 2026-01-19

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}
- **Diseases:** rheumatoid arthritis (MESH:D001172), venous ulcers (MESH:D014647), granulomatous disease (MESH:D006105), type 2 diabetes (MESH:D003924), ORCID IDs (MESH:C535742), fibrosis (MESH:D005355), ulcer (MESH:D014456), lipodermatosclerosis (MESH:C537026), infections (MESH:D007239), thyroid dysfunction (MESH:D013959), sarcoidosis (MESH:D012507), squamous cell carcinoma (MESH:D002294), pain (MESH:D010146), necrotic (MESH:D009336), heart disease (MESH:D006331), Inflammatory (MESH:D007249), pruritus (MESH:D011537), Chronic (MESH:D002908), metabolic syndrome (MESH:D024821), insulin-dependent diabetes (MESH:D003922), diabetes (MESH:D003920), trauma (MESH:D014947), NL (MESH:D009335), venous disease (MESH:D004194), edema (MESH:D004487), adrenal carcinoma (MESH:D000310), hypothyroidism (MESH:D007037)
- **Chemicals:** pentoxifylline (MESH:D010431), sulfamethoxazole-trimethoprim (MESH:D015662), Janus (-), hydroxychloroquine (MESH:D006886), silver (MESH:D012834), Hematoxylin (MESH:D006416), colchicine (MESH:D003078), D (MESH:D003903), gabapentin (MESH:D000077206), eosin (MESH:D004801)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12856615/full.md

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Source: https://tomesphere.com/paper/PMC12856615