Hetrombopag for the treatment of chemotherapy-induced thrombocytopenia in patients with solid tumors

TL;DR

This study shows hetrombopag is effective and safe for treating low platelet counts caused by chemotherapy in solid tumor patients.

Contribution

The study provides real-world evidence on hetrombopag's efficacy and safety for chemotherapy-induced thrombocytopenia in solid tumor patients.

Findings

79.5% of patients achieved complete platelet response within 14 days.

Combining hetrombopag with rhTPO/rhIL-11 reduced platelet response time significantly.

Hetrombopag was well-tolerated with minimal adverse events.

Abstract

Based on real-world research, we aimed to systematically evaluate the efficacy and safety of hetrombopag for the treatment of chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors. Patients with solid tumors who developed CIT (platelet count < 100 × 109/L) and were treated with hetrombopag in a single hospital between February 2022 and September 2023 were included in the study. The primary outcome was complete response rate within 14 days, defined as the proportion of patients with platelet counts of ≥100 × 109/L or platelet counts increased by at least 50 × 109/L from baseline. Response rate within 21 days, the incidence of chemotherapy intensity reduction, the median time of response, and adverse events were reported. A total of 73 patients met the inclusion criteria and were subsequently included in the analysis. The complete response rate within 14 days was 79.5%. Within 21 days, the complete response rate was 91.8%. The incidence of chemotherapy intensity reduction was 21.9%. The median time to platelet response was 9.0 days (95% CI, 8.3-9.7 days). The baseline platelet count of ≥ 50 × 109/L and the treatment regimen of hetrombopag combined with rhTPO/rhIL-11 were identified as independent favorable prognostic factors for platelet response time. Subgroup analyses demonstrated that patients receiving combination regimen exhibited a significantly reduced median time to platelet response with baseline platelet counts of ≥50 × 109/L. Safety profile showed good tolerability of hetrombopag (monotherapy or combined with rhTPO/rhIL-11) in patients. Hetrombopag may be an effective and well-tolerated treatment option for CIT in patients with solid tumors.

•Chemotherapy-induced thrombocytopenia (CIT) is a common problem for patients with solid tumor.•We retrospectively studied hetrombopag’s efficacy and safety and compared outcomes among different regimens.•Hetrombopag is an effective and well-tolerated treatment option for CIT in patients with solid tumor.•Hetrombopag plus rhTPO/rhIL-11 is an independent favorable factor for platelet response time.

Chemotherapy-induced thrombocytopenia (CIT) is a common problem for patients with solid tumor.

We retrospectively studied hetrombopag’s efficacy and safety and compared outcomes among different regimens.

Hetrombopag is an effective and well-tolerated treatment option for CIT in patients with solid tumor.

Hetrombopag plus rhTPO/rhIL-11 is an independent favorable factor for platelet response time.

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