# Emphysematous Pyelonephritis Revealing Underlying Renal Tuberculosis: A Rare and Challenging Association

**Authors:** Anass El Alaoui, Abdessamade Motaouakil, Mohammed Ramdani, Anouar El Moudane, Ali Barki

PMC · DOI: 10.7759/cureus.100462 · 2025-12-30

## TL;DR

A rare case of emphysematous pyelonephritis complicated by tuberculosis is reported, emphasizing the need for accurate diagnosis to prevent unnecessary surgery.

## Contribution

This case highlights the rare association of tuberculosis with emphysematous pyelonephritis.

## Key findings

- EPN was initially caused by typical bacterial pathogens.
- A superinfection with Mycobacterium tuberculosis occurred.
- Early recognition of tuberculosis is crucial to avoid unnecessary nephrectomy.

## Abstract

Emphysematous pyelonephritis (EPN) is a severe, necrotising infection of the renal parenchyma and surrounding tissues, most often accompanied by diabetes mellitus and Gram-negative bacilli. Tuberculosis superinfection is very rare, with only a few cases reported in the literature.

We present the case of a 61-year-old woman with multiple comorbidities, in whom emphysematous pyelonephritis (EPN) was primarily due to typical bacterial pathogens and subsequently complicated by a superinfection with Mycobacterium tuberculosis, highlighting the importance of recognizing this unusual secondary infection to avoid unnecessary nephrectomy.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076)
- **Species:** Mycobacterium tuberculosis (taxon 1773)

## Full-text entities

- **Diseases:** Tuberculosis (MESH:D014376), infection (MESH:D007239), Renal Tuberculosis (MESH:D014398), EPN (MESH:D011704), diabetes mellitus (MESH:D003920)
- **Species:** Mycobacterium tuberculosis (species) [taxon 1773], Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12856362/full.md

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Source: https://tomesphere.com/paper/PMC12856362