“The emerging role of lymphocytes in post-stroke inflammation: A treatable target and review of current pharmacological evidence in humans"

TL;DR

This paper reviews how lymphocytes influence post-stroke inflammation and recovery, and explores drugs that may help reduce inflammation after a stroke.

Contribution

The paper provides a comprehensive review of the role of B- and T-lymphocytes in post-stroke inflammation and evaluates current pharmacological evidence in humans.

Findings

B- and T-lymphocytes have distinct roles in influencing stroke recovery outcomes.

Post-stroke inflammation is a key therapeutic target for improving patient outcomes.

Several drugs show potential in modulating neuroinflammation or offering neuroprotection after stroke.

Abstract

Acute ischemic stroke is one of the leading causes of mortality and morbidity worldwide. The underlying inflammation process following the ischemic event arises as an important factor of great therapeutic interest. Recent research has showcased the roles of B- and T-lymphocytes in the acute post-stroke period, with various types of lymphocytes affecting differently the clinical outcome of the patient. Herein, we reviewed the literature and discussed the functional role of various subpopulations of lymphocytes in recovery and repair of the ischemic tissue as well as their influence on the final outcome of the patient. Additionally, we searched the literature regarding current knowledge on various drugs possibly affecting neuroinflammation or exhibiting a neuroprotective role in the acute post-stroke period.

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