# Rapid fracture healing of the greater tuberosity fragment after shoulder hemiarthroplasty in a patient with daily abaloparatide injection: A case report

**Authors:** Itsuo Joko, Mio Uchida, Masahito Hino, Shunsuke Miyaoka, Manabu Tanaka, Kazuo Kasuga, Nobuyuki Shimojo, Shigeharu Uchiyama

PMC · DOI: 10.1016/j.bonr.2026.101899 · 2026-01-15

## TL;DR

A 64-year-old woman experienced unusually fast bone healing after shoulder surgery, possibly due to abaloparatide treatment and a peripheral nerve injury.

## Contribution

This case report highlights an exceptional healing process linked to abaloparatide and peripheral nerve injury.

## Key findings

- Radiographic union of the greater tuberosity occurred 16 days after hemiarthroplasty.
- Remodelling was complete by 6 months postoperatively.
- Abaloparatide treatment and peripheral nerve injury may have contributed to accelerated healing.

## Abstract

We report a case of a 64-year-old woman who developed a 4-parts shoulder fracture-dislocation with peripheral nerve injury by the displaced fragment, during abaloparatide treatment. Following shoulder hemiarthroplasty, bone union at the greater tuberosity was achieved on postoperative day 16, with remodelling completed at 6 months postoperatively. This course was exceptionally favourable. Factors potentially contributing to the early bone union progression may include the coincidental administration of abaloparatide prior to trauma and the presence of peripheral nerve injury.

•Radiographic union of the greater tuberosity after hemiarthroplasty was seen at postoperative day 16.•Daily abaloparatide had been administered for 3 months before the injury.•Concomitant peripheral nerve injury may have influenced callus formation.•Remodelling appeared complete by 6 months postoperatively.

Radiographic union of the greater tuberosity after hemiarthroplasty was seen at postoperative day 16.

Daily abaloparatide had been administered for 3 months before the injury.

Concomitant peripheral nerve injury may have influenced callus formation.

Remodelling appeared complete by 6 months postoperatively.

## Linked entities

- **Chemicals:** abaloparatide (PubChem CID 76943386)

## Full-text entities

- **Diseases:** trauma (MESH:D014947), shoulder fracture (MESH:D012784), peripheral nerve injury (MESH:D059348), fracture (MESH:D050723), dislocation (MESH:D004204)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12856334/full.md

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Source: https://tomesphere.com/paper/PMC12856334