Global research landscape of ferroptosis in gastric cancer: a multidisciplinary bibliometric analysis based on multiple databases (2017-2025)

TL;DR

This paper maps global research on ferroptosis in gastric cancer from 2017 to 2025, identifying trends, key themes, and potential therapeutic targets.

Contribution

The study provides a multidisciplinary bibliometric analysis of ferroptosis in gastric cancer, highlighting its immunological implications and translational potential.

Findings

China leads in research output on ferroptosis in gastric cancer, followed by the US, Japan, Canada, and South Korea.

Key research themes include immune checkpoints, tumor immune microenvironment, and the STAT3–ferroptosis axis as translational targets.

Ferroptosis is increasingly seen as a promising strategy to enhance immunotherapy in gastric cancer.

Abstract

Ferroptosis, an iron-dependent regulated cell death mechanism, has recently gained attention for its crucial role in tumor progression and immune regulation. Gastric cancer (GC), one of the most common and deadly malignancies worldwide, remains a major clinical challenge. This study aims to systematically analyze the global research landscape, hotspots, and trends of ferroptosis in gastric cancer from 2017 to 2025, with a focus on its immunological implications.

Publications related to ferroptosis and gastric cancer published between January 1, 2017 and April 22, 2025 were retrieved from the Web of Science Core Collection (WoSCC) and Scopus databases (n = 974). Bibliometric and visualization analyses were performed using R software (bibliometrix package), VOSviewer, and CiteSpace to explore publication trends, collaboration patterns, keyword co-occurrence, and thematic evolution.

Research output showed a continuous upward trend, with China leading in publication volume, followed by the United States, Japan, Canada, and South Korea. Frontiers in Pharmacology and Frontiers in Oncology were the most productive journals, while Cell and Nature were the most frequently cited. The most prominent themes included “immune checkpoint,” “tumor immune microenvironment,” “ferroptosis mechanisms,” “drug resistance,” and “non-coding RNAs.” Notably, the STAT3–ferroptosis axis and immune pathways were identified as key translational targets.

Ferroptosis has become an important research frontier in gastric cancer and is increasingly recognized as a promising therapeutic strategy to modulate the tumor immune microenvironment and enhance immunotherapy efficacy. This study provides a comprehensive overview of the global research landscape, offering valuable guidance for future studies in cancer immunology and ferroptosis-based therapy.

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