The tooth transformer® revolution: autologous dentin biomaterials and platelet concentrates in oral regeneration. A parallel narrative systematic review
Gianna Dipalma, Grazia Marinelli, Laura Ferrante, Irma Trilli, Sharon Di Serio, Paola Bassi, Francesco Inchingolo, Andrea Palermo, Angelo Michele Inchingolo, Alessio Danilo Inchingolo
TL;DR
This review explores how autologous dentin grafts and platelet concentrates can aid in oral bone regeneration, suggesting they may work best together.
Contribution
The paper introduces a systematic review comparing autologous dentin grafts and platelet concentrates for oral regeneration, highlighting their complementary roles.
Findings
Autologous dentin grafts provide structural support with good volumetric stability and bone density.
Platelet concentrates enhance early healing and tissue maturation, especially in contained defects.
Combined use of these materials shows promise but needs validation through rigorous trials.
Abstract
Bone regeneration in oral and maxillofacial surgery remains a clinical challenge, particularly in cases of severe alveolar atrophy or large post-pathological bone defects. Autologous biomaterials including dentin grafts processed with the Tooth Transformer® device and platelet concentrates such as Concentrated Growth Factors (CGF), PRF, i-PRF, and TPRF—have gained attention due to their biocompatibility and regenerative potential. However, no direct head-to-head clinical studies comparing these autologous approaches are currently available. This review was conducted according to PRISMA 2020 guidelines. Literature searches were performed in PubMed, Scopus and Web of Science for clinical studies published in English between January 2010 and December 2025. Eligible designs included randomized trials, prospective/retrospective studies, and case series with ≥5 patients. Owing to the paucity…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34
Figure 35
Figure 36
Figure 37
Figure 38
Figure 39
Figure 40
Figure 41
Figure 42
Figure 43
Figure 44
Figure 45
Figure 46
Figure 47
Figure 48
Figure 49
Figure 50Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsPeriodontal Regeneration and Treatments · Dental Implant Techniques and Outcomes · Mesenchymal stem cell research