# The efficacy of acupuncture treatment for fibromyalgia syndrome: a systematic review and meta-analysis

**Authors:** Zhengfeng Ye, Chonghong Xue, Qirun Liu, Xingyi Li, Tianqi Yu, Hewei Wei

PMC · DOI: 10.3389/fmed.2025.1710642 · 2026-01-16

## TL;DR

This study reviews and analyzes research to determine if acupuncture helps reduce pain and improve symptoms in people with fibromyalgia syndrome.

## Contribution

A systematic review and meta-analysis of 17 RCTs to evaluate acupuncture's efficacy for fibromyalgia syndrome.

## Key findings

- Acupuncture significantly reduced pain and fatigue in fibromyalgia patients.
- It improved depression and lowered FIQ scores but did not significantly improve sleep quality.
- Results suggest the need for larger, high-quality studies to confirm these findings.

## Abstract

Fibromyalgia syndrome (FMS) is a common condition in rheumatology that affects patients' physical and mental health. Some studies have demonstrated the efficacy of acupuncture in alleviating pain in patients with FMS, but there is still insufficient evidence to support the improvement of pain and associated symptoms in FMS patients through acupuncture. Therefore, this study investigates whether acupuncture has therapeutic effects on patients with FMS.

We searched 8 databases to identify randomized controlled trials (RCTs) evaluating acupuncture interventions for FMS. We used ROB 2.0 tool to assess the risk of bias in selected studies. Heterogeneity among the studies was detected using the I2 test. Identifying sources of heterogeneity using subgroup analysis. Sensitivity analysis was performed to assess the stability of the results. Meta-analysis was performed using Stata 15.1.

17 RCTs involving 1,066 patients were included. Meta-analysis results showed that the intervention group had significantly lower VAS scores (SMD: −0.77; 95% CI: −1.00, −0.55), FIQ scores (SMD: −0.98; 95% CI: −1.43, −0.53), and the number of pain points (SMD: −1.36; 95% CI: −1.65, −1.08). It also improved depression and fatigue (SMD: −0.78; 95% CI: −1.10, −0.47) and fatigue (SMD: −0.51; 95% CI: −0.72, −0.30), P < 0.05, but did not significantly improve sleep quality (P > 0.05).

Acupuncture can reduce pain, improve depression and fatigue, and overall lower FIQ scores in the treatment of FMS. These findings require further confirmation through larger-scale, high-quality studies.

Identifier CRD20251120515

## Linked entities

- **Diseases:** fibromyalgia syndrome (MONDO:0005546)

## Full-text entities

- **Diseases:** FMS (MESH:D005356), fatigue (MESH:D005221), depression (MESH:D003866), pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12855461/full.md

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Source: https://tomesphere.com/paper/PMC12855461