# Literature review of leukoencephalopathy with calcifications and cysts and a case report

## TL;DR

This paper reviews LCC and presents a case where surgery and VEGF inhibitors helped manage symptoms and cysts.

## Contribution

The study provides a case report and treatment insights for managing LCC with surgical and pharmacological approaches.

## Key findings

- Surgical resection effectively reduced cysts and resolved symptoms in a LCC patient.
- VEGF inhibitors may benefit smaller, asymptomatic LCC cysts.
- Genetic testing confirmed SNORD118 variants in the patient.

## Abstract

To explore the clinical features and treatment approaches for leukoencephalopathy with calcifications and cysts (LCC).

We retrospectively analyzed a 22-year-old male patient with genetically confirmed LCC admitted to Qingdao University Affiliated Hospital in April 2019. The patient’s clinical presentation, imaging characteristics, treatment course, and outcomes were summarized alongside a comprehensive literature review.

The patient underwent resection of bilateral frontal lobe cysts followed later by resection of a parietal lobe cyst. Postoperative pathology confirmed LCC with calcification and cystic changes. No severe postoperative complications occurred. Follow-up imaging demonstrated gradual cyst regression and symptom resolution. Genetic testing identified heterozygous SNORD118 variants (n.3C>T and n.74G>A).

Surgical resection is an effective treatment for LCC cysts causing significant mass effect or neurological deficits, requiring regular follow-up. For smaller, asymptomatic cysts without mass effect, treatment with VEGF inhibitors (e.g., bevacizumab) may be beneficial. Management should be individualized.