# A Randomized Controlled Trial of Botulinum Toxin Combined with Non-Cross-Linked Bovine Collagen for Improving Periorbital Wrinkles

## TL;DR

A study found that combining botulinum toxin and bovine collagen injections significantly improves periorbital wrinkles more effectively than using botulinum toxin alone.

## Contribution

The novel contribution is demonstrating the enhanced efficacy of combining botulinum toxin with non-cross-linked bovine collagen for treating periorbital wrinkles.

## Key findings

- The observation group had a 90% markedly effective rate compared to 40% in the control group.
- 95% of patients in the observation group reported high satisfaction versus 20% in the control group.
- No adverse events were reported in either group during the study.

## Abstract

This study examined the clinical efficacy of botulinum toxin type A (BTX-A) combined with non-cross-linked bovine collagen in improving periorbital wrinkles.

Forty participants with periorbital wrinkles were recruited from the Plastic Surgery and Aesthetic Department of the Central Hospital Affiliated to Dalian University of Technology in China between November 2021 and August 2022. Participants were randomly assigned to either an observation group or a control group, with each group comprising 20 participants. The control group received BTX-A injection alone, whereas the observation group received combined injections of BTX-A and collagen filler.

Standardized photographic images were taken at baseline and at 1-week, 1-month, 3-month, and 6-month follow-ups after the injection. The rejuvenation effect was evaluated using the 5-grade Wrinkle Severity Rating Scale, whereas patient satisfaction was assessed using the Global Aesthetic Improvement Scale. Both groups achieved a total effective rate of 100%. However, the markedly effective rate was significantly higher in the observation group (90%) than in the control group (40%; p < 0.01). Moreover, 95% patients in the observation group reported great satisfaction, and the percentage was significantly higher than that in the control group (20%; p < 0.01). No adverse events were reported during the study.

BTX-A injections combined with non-cross-linked bovine collagen filler provide a highly effective and safe therapy for improving periorbital wrinkles.

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