# Commentary: Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

**Authors:** Jintao Cui, Bin Xu, Penghui Zhang, Songfu Han, Chaoyanng Guo, Limin Wei

PMC · DOI: 10.3389/fimmu.2025.1752400 · 2026-01-16

## Full-text entities

- **Genes:** AKR1A1 (aldo-keto reductase family 1 member A1) [NCBI Gene 10327] {aka ALDR1, ALR, ARM, DD3, HEL-S-6}
- **Diseases:** osteoporosis (MESH:D010024)

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Source: https://tomesphere.com/paper/PMC12855118