The concurrence of lung malignancies and organizing pneumonia

TL;DR

This study shows that organizing pneumonia in lung biopsies can sometimes be linked to undiagnosed lung cancer, highlighting the need for careful follow-up.

Contribution

The study identifies a significant association between organizing pneumonia and lung malignancy, especially in minimally invasive biopsy cases.

Findings

76% of prior biopsies in Cohort 1 showed malignancy, but none revealed organizing pneumonia due to its focal nature.

7.5% of patients in Cohort 2 with organizing pneumonia diagnosed via bronchoscopy were later found to have lung cancer.

Abstract

Organizing pneumonia (OP) is often considered a benign finding, but in some cases, it may be associated with underlying malignancy. With the increasing use of minimally invasive biopsy techniques, understanding the relationship between OP and lung cancer is critical to avoid delayed or missed diagnoses. This study aims to evaluate the prevalence of OP and lung malignancy and report characteristics of these cases.

A retrospective review was conducted of all lung pathology reports at Indiana University from January 1, 2010, to January 1, 2023, encompassing over 8,000 cases. Cases with histopathologic diagnoses of OP with and without lung malignancy were identified; relevant clinical, radiologic, and follow-up data were extracted. Using language extraction, we identified pathology cases showing both organizing pneumonia and carcinoma (Cohort 1) and transbronchial biopsies identified as “organizing pneumonia” (Cohort 2). Cohort 2 was selected to reflect current clinical practice.

In Cohort 1 (n=57), 88% of samples demonstrating both organizing pneumonia and malignancy were obtained via surgical resection. Among these, squamous cell carcinoma accounted for 46% and adenocarcinoma for 37% of cases, with all T-stages represented (44% T1, 29% T2, 16% T3, and 11% T4). In this cohort, thirty-eight prior biopsy samples prior to surgery were reviewed; 76% revealed malignancy, but none showed definitive organizing pneumonia likely due to focal nature of OP. Cohort 2 (n=40), 7.5% of patients in whom organizing pneumonia was identified through minimally invasive bronchoscopic sampling were ultimately diagnosed with concurrent lung cancer. All required repeat tissue sampling for cancer diagnosis.

Lung malignancy is known to be associated with OP. A high degree of suspicion should be maintained if OP is found on minimally invasive techniques, particularly if malignancy is strongly suspected.

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